反应详情

温度

0 °C

The above 5-trifluoromethoxyanthranilic acid (68.8 g, 0.31 mol) is suspended in a mixture of concentrated HCl (50 mL) and water (300 mL), cooled to 0° C. and stirred. Sodium nitrite (24.2 g 0.35 mol) dissolved in water (50 mL) is slowly added taking care to maintain the temperature of the reaction mixture below 5° C. Stirring is continued at 0° C. for 30 minutes. Potassium iodide (91 g, 0.55 mol) is dissolved in a mixture of concentrated H2SO4 (19 mL) and water (130 mL) and added dropwise to the reaction mixture while keeping the temperature of the reaction mixture below 10° C. The mixture is then heated to 100° C. and stirred for 2 hours. After cooling to room temperature, the mixture is partitioned between EtOAc (1000 mL) and saturated sodium bisulfite solution (500 mL). The organic layer is washed again with saturated sodium bisulfite solution (500 mL) and then brine (500 mL), dried (MgSO4) and concentrated by rotary evaporator to give 5-trifluoromethoxy-2-iodobenzoic acid.

1. additionis slowly added
2. temperatureto maintain the temperature of the reaction mixture below 5° C
3. stirringStirring
4. additionadded dropwise to the reaction mixture
5. customthe temperature of the reaction mixture below 10° C
6. temperatureThe mixture is then heated to 100° C.
7. stirringstirred for 2 hours
8. temperatureAfter cooling to room temperature
9. customthe mixture is partitioned between EtOAc (1000 mL) and saturated sodium bisulfite solution (500 mL)
10. washThe organic layer is washed again with saturated sodium bisulfite solution (500 mL)
11. dry with materialbrine (500 mL), dried (MgSO4)
12. concentrationconcentrated by rotary evaporator