Triethylamine → HCID 11696392, compound

HRID 1270807Notes

Reaction equation

HRID 1270807 reaction equation
[OH:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5](/[CH:10]=[CH:11]/[CH:12]=[CH:13]/[C:14]([OH:16])=O)=[CH:4][C:3]=1[O:17][CH3:18].Br.[OH:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[OH:29])[CH2:24][NH2:25].C(N(CC)CC)C.CN([P+](ON1N=NC2C=CC=CC1=2)(N(C)C)N(C)C)C.F[P-](F)(F)(F)(F)F>>[OH:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[OH:29])[CH2:24][NH:25][C:14](=[O:16])/[CH:13]=[CH:12]/[CH:11]=[CH:10]/[C:5]1[CH:4]=[C:3]([O:17][CH3:18])[C:2]([OH:1])=[C:7]([O:8][CH3:9])[CH:6]=1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 133435624-(Aminomethyl)benzene-1,2-diol--hydrogen bromide (1/1)HCID 18451611HCID 18451611, compound

Product 1

HCID 11696392HCID 11696392, compound

Procedure

The compound was prepared based on the methodology in Example 5 using 38 mg (0.15 mmol) of 5-(4-hydroxy-3,5-dimethoxyphenyl)-penta-2E,4E-dienoic acid [Example 4], 67 mg (0.30 mmol) of 3,4 dihydroxybenzylamine hydrobromide, 153 μl (1.5 mmol) of triethylamine, and 100 mg (0.23 mmol) of BOP reagent.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-8fb2b568cabc46389bf8a03d2fb07133
Source dataset
uspto-grants-2007_04
Patent number
US07202383B2

Reaction notes

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