HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 3-(5-Phenyl-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3-(2-oxo-2-phenyl-ethylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert butyl ester | HCID 23570725 | — |
| Reactant | 3-(2-oxo-2-phenyl-ethylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester | HCID 66892649 | — |
| Product | 3-(5-Phenyl-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline | HCID 22147680 | — |
Reaction Steps
Dehydration of 3-(2-oxo-2-phenyl-ethylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester (prepared in a similar manner as 3-(2-oxo-2-phenyl-ethylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert butyl ester of Example 1) with POCl3 yields the following intermediate compound:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07202381B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-82170f561d654ef9a7b48231ad9a19ae |
| Source note | uspto-grants-2007_04 |