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HRID127097

反应详情

EQUATION

反应方程式

HRID 127097 的结构方程式

REACTANTS

反应物

4
结构：ClP(Cl)(Cl)(Cl)Cl
HCID24819

Phosphorus pentachloride

Cl5P

结构：C[Si](C)(C)CC(N)=O
HCID357676

Acetamide, 2-(trimethylsilyl)-

C5H13NOSi

结构：CS(=O)(=O)Nc1nc(CC(=O)O)cs1
HCID3159575

{2-[(Methanesulfonyl)amino]-1,3-thiazol-4-yl}acetic acid

C6H8N2O4S2

结构：NC(=O)OCC1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1
HCID12784759

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)NC1S[C@@H]2C(c3csc(NS(C)(=O)=O)n3)C(=O)N2C(C(=O)O)=C1COC(N)=O
HCID131712109

未命名化合物

收率 76.1%

PROCEDURE

实验过程

2-Methanesulfonamidothiazol-4-ylacetic acid (1.13 g.), 3-carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acid (1.37 g.), phosphorus pentachloride (2.08 g.) and trimethylsilylacetamide (4.58 g.) were treated in the similar manner to that of Example 12 to give 3-carbamoyloxymethyl-7-(2-methanesulfonamidothiazol-4-yl)-acetamido-3-cephem-4-carboxylic acid (1.79 g.)