HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → 3-Carbamoyloxymethyl-7-(2-methanesulfonamidothiazol-4-yl)-acetamido-3-cephem-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | Acetamide, 2-(trimethylsilyl)- | HCID 357676 | — |
| Reactant | 2-(2-Methanesulfonamido-1,3-thiazol-4-yl)acetic acid | HCID 3159575 | — |
| Reactant | 3-Carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acid | HCID 12784759 | — |
| Product | 3-Carbamoyloxymethyl-7-(2-methanesulfonamidothiazol-4-yl)-acetamido-3-cephem-4-carboxylic acid | HCID 131712109 | 76.1% |
Reaction Steps
2-Methanesulfonamidothiazol-4-ylacetic acid (1.13 g.), 3-carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acid (1.37 g.), phosphorus pentachloride (2.08 g.) and trimethylsilylacetamide (4.58 g.) were treated in the similar manner to that of Example 12 to give 3-carbamoyloxymethyl-7-(2-methanesulfonamidothiazol-4-yl)-acetamido-3-cephem-4-carboxylic acid (1.79 g.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04254260 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-3e7bd264c207483e9db2c231d0436d0c |
| Source note | uspto-grants-1981_03 |