Benzyl Bromide → HCID 69471538, compound

HRID 1271006Notes

Reaction equation

HRID 1271006 reaction equation
[F:1][CH2:2][C:3]([NH2:5])=[S:4].[CH2:6]([Br:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl.CCOCC>[BrH:13].[CH2:6]([S:4][C:3](=[NH:5])[CH2:2][F:1])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 7498Benzyl BromideHCID 16737206HCID 16737206, compound

Product 1

HCID 69471538HCID 69471538, compoundYield 54%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

Fluorothioacetamide (3.39 g) and benzyl bromide (6.23 g) were refluxed in chloroform (40 ml), under nitrogen, for 16 h. After colling, the mixture was diluted with ether (200 ml) and the resulting orange solid filtered off. The solid was washed with more ether and dried over P2O5 in vacuo to give 5.19 g of the desired product.

Workup

  1. filtrationthe resulting orange solid filtered off
  2. washThe solid was washed with more ether
  3. dry with materialdried over P2O5 in vacuo

Sources & evidence

ORD record
ord-129a09d650754e23b0d382883123fa6c
Source dataset
uspto-grants-2007_04
Patent number
USRE039576E1

Reaction notes

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