Hydrochloric Acid → HCID 70572744, compound

HRID 127105Notes

Reaction equation

HRID 127105 reaction equation
[OH-:1].[K+].[CH3:3][S:4]([NH:7][C:8]1[S:9][C:10](CC(OCC)=O)=[CH:11][N:12]=1)(=[O:6])=[O:5].Cl.[CH2:20]([OH:22])[CH3:21]>>[CH3:3][S:4]([NH:7][C:8]1([CH2:21][C:20]([OH:1])=[O:22])[NH:12][CH:11]=[CH:10][S:9]1)(=[O:5])=[O:6]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 20288652Ethyl {2-[(methanesulfonyl)amino]-1,3-thiazol-5-yl}acetate

Product 1

HCID 70572744HCID 70572744, compound

Procedure

To a solution of 1 N potassium hydroxide aqueous solution (246 ml.) in ethanol (52 ml.) was added ethyl 2-methanesulfonamidothiazol-5-ylacetate (26 g.) over 1 minutes under ice-cooling and stirring, and the mixture was stirred for about 5 minutes to produce a homogeneous solution. The solution was further stirred for 5 minutes and adjusted to pH 2 with 10% hydrochloric acid under ice-cooling and then stirred for 20 minutes at the same temperature. The precipitated crystals were collected by filtration, air-dried overnight and then dried over phosphorus pentoxide to give colorless crystals of 2-methanesulfonamidothiazol-2-ylacetic acid (16.6 g.), mp 232° to 234° C. (dec.).

Workup

  1. temperaturecooling
  2. stirringthe mixture was stirred for about 5 minutes
  3. customto produce a homogeneous solution
  4. stirringThe solution was further stirred for 5 minutes
  5. temperaturecooling
  6. stirringstirred for 20 minutes at the same temperature
  7. filtrationThe precipitated crystals were collected by filtration
  8. customair-dried overnight
  9. dry with materialdried over phosphorus pentoxide

Sources & evidence

ORD record
ord-f8994a86be674de7b6e513675dcce447
Source dataset
uspto-grants-1981_03
Patent number
US04254260

Reaction notes

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