反应详情

Analogous to the method described in Example 1, 2-(chlorocarbonyl)-4,5-difluorophenyl acetate (0.2 g, 0.85 mmol) and methyl 4-aminobenzoate (0.174 g, 1.1 mmol) were coupled to yield methyl 4-(4,5-difluoro-2-hydroxybenzamido)benzoate (0.186 g, 64%). RP-HPLC: 2.61 min; ES-MS (M+H)+=308.0.