Methyl morpholine oxide → 8-Fluoro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-6-carboxaldehyde

Intermediate 23 was reacted to form 8-fluoro-6-hydroxymethyl-4H-benzo[1,4]oxazin-3-one in an analogous manner to intermediate 3. 1H NMR (DMSO-d6) δ 4.34 (s, 2H), 4.59 (s, 2H), 6.66 (s, 1H), 6.74 (s, 1H), 6.7 (s, 1H), 10.86 (bs, 1H). To a solution of 8-fluoro-6-hydroxymethyl-4H-benzo[1,4]oxazin-3-one (4.75 g, 24.09 mmol) in dichloromethane (250 mL) at room temperature was added 4-methylmorpholine-N-oxide (4.23 g, 36.1 mmol), TPAP (tetraproplyammonium perruthenate) (0.042 g, 1.2 mmol), and 4A molecular sieves (0.500 g). The reaction was stirred for overnight. The reaction mixture was then filtered through a pad of celite. The celite cake was washed with dichloromethane (100 mL). The solution was then concentrated under reduced pressure to yield a dark oil. This solution was then filtered through SiO2 and washed with ethyl acetate to remove final traces of the TPAP catalyst to yield the title compound. MS: M+−1=194.1 Da.

1. filtrationThe reaction mixture was then filtered through a pad of celite
2. washThe celite cake was washed with dichloromethane (100 mL)
3. concentrationThe solution was then concentrated under reduced pressure
4. customto yield a dark oil
5. filtrationThis solution was then filtered through SiO2
6. washwashed with ethyl acetate
7. customto remove final traces of the TPAP catalyst

ORD record

ord-3e8f37b765a74e93a7e761c5e1d9425d

Source dataset

uspto-grants-2007_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07205295B2