Acetone → HCID 18452865, compound

HRID 1271219Notes

Reaction equation

HRID 1271219 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[N:6][CH:7]=1.[CH3:8][C:9]([CH3:11])=O.[H][H]>C(O)C.O=[Pt]=O>[CH:9]([NH:1][C:2]1[CH:3]=[N:4][CH:5]=[N:6][CH:7]=1)([CH3:11])[CH3:8]

Participants

6

Reactant 3

HCID 180AcetoneHCID 344373Pyrimidin-5-amine2×HCID 178418361HCID 178418361, compound

Product 1

HCID 18452865HCID 18452865, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A suspension of the 5-aminopyrimidine, and one twenty-fifth an equal mass of PtO2, and 1.1 equivalents acetone, in ethanol solvent, was shaken under 60 psi hydrogen gas for 24 h. At this time, TLC of an evaporated aliquot of the reaction mixture indicated complete conversion of the 5-aminopyrimidine. The Pt catalyst was removed by filtering the reaction mixture through Celite, and the 5-(N-isopropyl)aminopyrimidine was isolated by evaporation of the ethanol solvent. The crude product was used in subsequent chemical steps without purification.

Workup

  1. customThe Pt catalyst was removed
  2. filtrationby filtering the reaction mixture through Celite

Sources & evidence

ORD record
ord-1a23425595094517937d51b085e4b9bc
Source dataset
uspto-grants-2007_04
Patent number
US07205310B2

Reaction notes

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