反应详情

5% platinum-carbon was suspended in 10 ml of methanol and a solution of 3.00 g of 3-(methoxymethoxy)benzaldehyde in 10 ml of methanol and 2.1 ml of 40% methylamine (methanol solution) were added. After heating to 30° C. under 2 atm, hydrogen was added for 22 hours. A catalyst was removed by filtering the reaction solution and the filtrate was concentrated. The residue was purified by silica gel column chromatography to obtain 2.51 g of the desired compound as a yellowish oily substance.

1. additionwas added for 22 hours
2. customA catalyst was removed
3. filtrationby filtering the reaction solution
4. concentrationthe filtrate was concentrated
5. customThe residue was purified by silica gel column chromatography