Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → 2-[4-hydroxy-(Z)-2-buten-1-yloxy]acetic Acid Tert-Butyl Ester

Participants

Reaction Steps

To a solution of 1.00 g of 2-[4-(2-tetrahydropyranyloxy)-(Z)-2-buten-1-yloxy]acetic acid tert-butyl ester in 30 ml of methanol, 88 mg of pyridinium p-toluenesulfonate was added and the mixture was heated at reflux for 3 hours. The solvent was evaporated under reduced pressure and the reaction solution was extracted with ethyl acetate after adding water. After the extract was dried over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure to obtain 420 mg of the desired compound as an oily substance.

Provenance & Evidence