反应详情

To a solution of 1.00 g of 2-[4-(2-tetrahydropyranyloxy)-(Z)-2-buten-1-yloxy]acetic acid tert-butyl ester in 30 ml of methanol, 88 mg of pyridinium p-toluenesulfonate was added and the mixture was heated at reflux for 3 hours. The solvent was evaporated under reduced pressure and the reaction solution was extracted with ethyl acetate after adding water. After the extract was dried over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure to obtain 420 mg of the desired compound as an oily substance.

1. temperaturethe mixture was heated
2. temperatureat reflux for 3 hours
3. customThe solvent was evaporated under reduced pressure
4. extractionthe reaction solution was extracted with ethyl acetate
5. additionafter adding water
6. dry with materialAfter the extract was dried over anhydrous magnesium sulfate
7. customthe solvent was evaporated under reduced pressure