反应详情

To 1.00 g of 5-chloro-2,3-diphenylpyrazine 1-oxide, 20 ml of 40% methylamine in methanol was added and the mixture was-reacted in a sealed tube at room temperature for 15 hours. The reaction solution was extracted with ethyl acetate after adding water. The extract was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The resulting crude crystal was washed with diisopropyl ether to obtain 536 mg of the desired compound as a pale yellow crystal having a melting point of 145 to 147° C.

1. customthe mixture was-reacted in a sealed tube at room temperature for 15 hours
2. extractionThe reaction solution was extracted with ethyl acetate
3. additionafter adding water
4. dry with materialThe extract was dried over anhydrous magnesium sulfate
5. customthe solvent was evaporated under reduced pressure
6. washThe resulting crude crystal was washed with diisopropyl ether