HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon tetrabromide → 1-bromo-4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 4-((5,6-Diphenyl-Pyrazin-2-yl)(isopropyl)amino)butan-1-ol | HCID 18452655 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-bromo-4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butane | HCID 18452633 | 67% |
Reaction Steps
A solution of 1.50 g of 4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]-1-butanol and 1.18 g of triphenylphosphine in 20 ml of dichloromethane was ice-cooled and 1.49 g of carbon tetrabromide was added. After stirring for one hour, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 1.18 g of the desired compound as a yellow oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07205302B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-d9ce396ae15c4a31be8357229d17fd7f |
| Source note | uspto-grants-2007_04 |