Carbon tetrabromide → 1-bromo-4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butane

HRID 1271270노트

반응식

HRID 1271270 반응식
[C:1]1([C:7]2[N:8]=[CH:9][C:10]([N:19]([CH2:23][CH2:24][CH2:25][CH2:26]O)[CH:20]([CH3:22])[CH3:21])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:48]>ClCCl>[Br:48][CH2:26][CH2:25][CH2:24][CH2:23][N:19]([C:10]1[CH:9]=[N:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:11]=1)[CH:20]([CH3:22])[CH3:21]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 184526554-((5,6-Diphenyl-Pyrazin-2-yl)(isopropyl)amino)butan-1-ol

생성물 1

HCID 184526331-bromo-4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butane수율 67%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1.50 g of 4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]-1-butanol and 1.18 g of triphenylphosphine in 20 ml of dichloromethane was ice-cooled and 1.49 g of carbon tetrabromide was added. After stirring for one hour, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 1.18 g of the desired compound as a yellow oily substance.

후처리

  1. temperaturecooled
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-d9ce396ae15c4a31be8357229d17fd7f
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205302B2

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