反应详情

A solution of 1.50 g of 4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]-1-butanol and 1.18 g of triphenylphosphine in 20 ml of dichloromethane was ice-cooled and 1.49 g of carbon tetrabromide was added. After stirring for one hour, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 1.18 g of the desired compound as a yellow oily substance.

1. temperaturecooled
2. customthe solvent was evaporated under reduced pressure
3. customThe residue was purified by silica gel column chromatography