Morpholine → 4-Morpholinesulfonamide
Reaction equation
[S:1]([NH2:5])([NH2:4])(=[O:3])=[O:2].N1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1.C(OCCOCC)C>>[N:4]1([S:1]([NH2:5])(=[O:3])=[O:2])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1Participants
4
Conditions
- Temperature
- 120 °C
Procedure
5.00 g of sulfamide, 4.09 g of morpholine and 5 ml of 1,2-diethoxyethane were mixed and heated with stirring in an oil bath at 120° C. for 11 hours. The reaction solution was air-cooled to room temperature and the crystal was washed with diethyl ether, washed with methanol and then dried under reduced pressure to obtain 5.98 g of the desired compound as an brownish crystal having a melting point of 158 to 161° C.
Workup
- temperatureheated
- temperatureThe reaction solution was air-cooled to room temperature
- washthe crystal was washed with diethyl ether
- washwashed with methanol
- customdried under reduced pressure
Sources & evidence
- ORD record
- ord-5d3ae64b05b54a638eab3d448eed5fa9
- Source dataset
- uspto-grants-2007_04
- Patent number
- US07205302B2
Reaction notes
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