5-Chloro-2,3-Diphenylpyrazine → (+/-)-1-[1-(5,6-Diphenylpyrazin-2-yl)pyrrolidin-2-yl]-4-(2-tetrahydropyranyloxy)butane

HRID 1271276Notes

Reaction equation

HRID 1271276 reaction equation
Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[NH:20]1[CH2:24][CH2:23][CH2:22][CH:21]1[CH2:25][CH2:26][CH2:27][CH2:28][O:29][CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][O:31]1>>[C:8]1([C:5]2[N:6]=[CH:7][C:2]([N:20]3[CH2:24][CH2:23][CH2:22][CH:21]3[CH2:25][CH2:26][CH2:27][CH2:28][O:29][CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][O:31]3)=[N:3][C:4]=2[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 36544935-Chloro-2,3-DiphenylpyrazineHCID 13996766(+/-)-1-(2-Pyrrolidinyl)-4-(2-tetrahydropyranyloxy)butane

Product 1

HCID 22931951(+/-)-1-[1-(5,6-Diphenylpyrazin-2-yl)pyrrolidin-2-yl]-4-(2-tetrahydropyranyloxy)butane

Procedure

In the same manner as in the step 1 of Example 9, except that 2-chloro-5,6-diphenylpyrazine was used in place of 2-chloro-5,6-di-p-tolylpyrazine and (±)-1-(2-pyrrolidinyl)-4-(2-tetrahydropyranyloxy)butane was used in place of 4-(methylamino)-1-butanol, the desired compound was prepared as a yellowish crystal having a melting point of 94 to 96° C.

Sources & evidence

ORD record
ord-7faec92021c84fc6b737b228d30aa816
Source dataset
uspto-grants-2007_04
Patent number
US07205302B2

Reaction notes

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