5-Chloro-2,3-Diphenylpyrazine → (+/-)-1-[1-(5,6-Diphenylpyrazin-2-yl)pyrrolidin-2-yl]-4-(2-tetrahydropyranyloxy)butane

Participants

Reaction Steps

In the same manner as in the step 1 of Example 9, except that 2-chloro-5,6-diphenylpyrazine was used in place of 2-chloro-5,6-di-p-tolylpyrazine and (±)-1-(2-pyrrolidinyl)-4-(2-tetrahydropyranyloxy)butane was used in place of 4-(methylamino)-1-butanol, the desired compound was prepared as a yellowish crystal having a melting point of 94 to 96° C.

Provenance & Evidence