5-Chloro-2,3-Diphenylpyrazine → 1-{[N-(5,6-diphenylpyrazin-2-yl)-N-methylamino]methyl}-3-(methoxymethoxy)benzene

HRID 1271282Notes

Reaction equation

HRID 1271282 reaction equation
Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[CH3:20][O:21][CH2:22][O:23][C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=1)[CH2:27][NH:28][CH3:29]>>[C:8]1([C:5]2[N:6]=[CH:7][C:2]([N:28]([CH2:27][C:26]3[CH:30]=[CH:31][CH:32]=[C:24]([O:23][CH2:22][O:21][CH3:20])[CH:25]=3)[CH3:29])=[N:3][C:4]=2[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 36544935-Chloro-2,3-DiphenylpyrazineHCID 229319963-(methoxymethoxy)-N-methylbenzylamine

Product 1

HCID 184526351-{[N-(5,6-diphenylpyrazin-2-yl)-N-methylamino]methyl}-3-(methoxymethoxy)benzene

Procedure

In the same manner as in the step 1 of Example 9, except that 2-chloro-5,6-diphenylpyrazine was used in place of 2-chloro-5,6-di-p-tolylpyrazine and 3-(methoxymethoxy)-N-methylbenzylamine was used in place of 4-(methylamino)-1-butanol, the desired compound was prepared as a colorless crystal having a melting point of 109 to 111° C.

Sources & evidence

ORD record
ord-805214c5feda4e3c8b4c285d50e912d6
Source dataset
uspto-grants-2007_04
Patent number
US07205302B2

Reaction notes

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