2,3-Diphenyl-5-(methylamino)pyrazine 1-oxide → 2,3-diphenyl-5-{N-[4-(tert-butoxycarbonylmethoxy)butyl]-N-methylamino}pyrazine 1-oxide

HRID 1271291Notes

Reaction equation

HRID 1271291 reaction equation
[C:1]1([C:7]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:11][C:10]([NH:19][CH3:20])=[CH:9][N+:8]=2[O-:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:22]([O:26][C:27](=[O:35])[CH2:28][O:29][CH2:30][CH2:31][CH2:32][CH2:33]Br)([CH3:25])([CH3:24])[CH3:23]>>[C:1]1([C:7]2[C:12]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[N:11][C:10]([N:19]([CH2:33][CH2:32][CH2:31][CH2:30][O:29][CH2:28][C:27]([O:26][C:22]([CH3:23])([CH3:25])[CH3:24])=[O:35])[CH3:20])=[CH:9][N+:8]=2[O-:21])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 229320102,3-Diphenyl-5-(methylamino)pyrazine 1-oxideHCID 86592459Tert-butyl (4-bromobutyloxy)acetate

Product 1

HCID 229319842,3-diphenyl-5-{N-[4-(tert-butoxycarbonylmethoxy)butyl]-N-methylamino}pyrazine 1-oxide

Procedure

In the same manner as in Example 22, except that 2,3-diphenyl-5-(methylamino)pyrazine 1-oxide was used in place of 5,6-diphenyl-2-(methylamino)pyrazine and 2-(4-bromobutyloxy)acetic acid tert-butyl ester was used in place of 2-(4-bromobutyloxy)acetic acid methyl ester, the desired compound was prepared as a pale yellow oily substance.

Sources & evidence

ORD record
ord-6f65e69dfaf445298e4979cdcbd0bc42
Source dataset
uspto-grants-2007_04
Patent number
US07205302B2

Reaction notes

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