4,5-Diphenyl-2-(methylamino)pyrimidine → 2-{4-[N-(4,5-diphenylpyrimidin-2-yl)-N-methylamino]butyloxy}acetic Acid Tert-Butyl Ester

HRID 1271292Notes

Reaction equation

HRID 1271292 reaction equation
[C:1]1([C:7]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:11][N:10]=[C:9]([NH:19][CH3:20])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:21]([O:25][C:26](=[O:34])[CH2:27][O:28][CH2:29][CH2:30][CH2:31][CH2:32]Br)([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26](=[O:34])[CH2:27][O:28][CH2:29][CH2:30][CH2:31][CH2:32][N:19]([C:9]1[N:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:11][N:10]=1)[CH3:20])([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 229319754,5-Diphenyl-2-(methylamino)pyrimidineHCID 86592459Tert-butyl (4-bromobutyloxy)acetate

Product 1

HCID 693546782-{4-[N-(4,5-diphenylpyrimidin-2-yl)-N-methylamino]butyloxy}acetic Acid Tert-Butyl Ester

Procedure

In the same manner as in Example 22, except that 4,5-diphenyl-2-(methylamino)pyrimidine was used in place of 5,6-diphenyl-2-(methylamino)pyrazine and 2-(4-bromobutyloxy)acetic acid tert-butyl ester was used in place of 2-(4-bromobutyloxy)acetic acid methyl ester, the desired compound was prepared as a pale yellow oily substance.

Sources & evidence

ORD record
ord-5d0a30ff279f4122bf24419a1ca132f3
Source dataset
uspto-grants-2007_04
Patent number
US07205302B2

Reaction notes

Loading…