4,5-Di-p-tolyl-2-(methylamino)pyrimidine → 2-{4-[N-(4,5-di-p-tolylpyrimidin-2-yl)-N-methylamino]butyloxy}acetic Acid Tert-Butyl Ester

HRID 1271293Notes

Reaction equation

HRID 1271293 reaction equation
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([C:7]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=3)=[CH:11][N:10]=[C:9]([NH:20][CH3:21])[N:8]=2)=[CH:3][CH:2]=1.[C:23]([O:27][C:28](=[O:36])[CH2:29][O:30][CH2:31][CH2:32][CH2:33][CH2:34]Br)([CH3:26])([CH3:25])[CH3:24]>>[C:23]([O:27][C:28](=[O:36])[CH2:29][O:30][CH2:31][CH2:32][CH2:33][CH2:34][N:20]([C:9]1[N:8]=[C:7]([C:4]2[CH:3]=[CH:2][C:1]([CH3:22])=[CH:6][CH:5]=2)[C:12]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)=[CH:11][N:10]=1)[CH3:21])([CH3:26])([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 229319594,5-Di-p-tolyl-2-(methylamino)pyrimidineHCID 86592459Tert-butyl (4-bromobutyloxy)acetate

Product 1

HCID 693553212-{4-[N-(4,5-di-p-tolylpyrimidin-2-yl)-N-methylamino]butyloxy}acetic Acid Tert-Butyl Ester

Procedure

In the same manner as in Example 22, except that 4,5-di-p-tolyl-2-(methylamino)pyrimidine was used in place of 5,6-diphenyl-2-(methylamino)pyrazine and 2-(4-bromobutyloxy)acetic acid tert-butyl ester was used in place of 2-(4-bromobutyloxy)acetic acid methyl ester, the desired compound was prepared as a pale yellow oily substance.

Sources & evidence

ORD record
ord-f2b89caa543e49e9862bb469ba76c4f0
Source dataset
uspto-grants-2007_04
Patent number
US07205302B2

Reaction notes

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