Hydrochloric Acid → 5-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 12713Notes

Reaction equation

HRID 12713 reaction equation
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.O1CCOCC1.[ClH:24]>>[ClH:24].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 589941555-(2-Fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine

Product 1

HCID 686945025-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

Procedure

A solution of 5-(2-fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine (Prep87, 2.8 g, 11.90 mmol) in HCl 4M in 1,4dioxane (42 mL, 168 mmol) was heated at 90° C. for 1 h. A white precipitate crashed out of the solution. Volatiles were evaporated under reduced pressure to give title compound, pale yellow solid (2.75 g).

Workup

  1. customVolatiles were evaporated under reduced pressure

Sources & evidence

ORD record
ord-7dfa12c1ad044b53834cd890affd01db
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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