Sodium Hydroxide → HCID 69354385, compound

HRID 1271307Notes

Reaction equation

HRID 1271307 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]([C:15]1[C:20]([CH3:21])=[N:19][C:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:17]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:16]=1)[CH3:14])(C)(C)C.C1(C2N=C(C)C(N(CCCCOCC(O)=O)C)=NC=2C2C=CC=CC=2)C=CC=CC=1.[OH-].[Na+:66]>>[Na+:66].[C:22]1([C:18]2[N:19]=[C:20]([CH3:21])[C:15]([N:13]([CH2:12][CH2:11][CH2:10][CH2:9][O:8][CH2:7][C:6]([O-:34])=[O:5])[CH3:14])=[N:16][C:17]=2[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 18452644HCID 18452644, compoundHCID 69356828HCID 69356828, compound

Product 1

HCID 69354385HCID 69354385, compound

Procedure

After 2-{4-[N-(5,6-diphenyl-3-methylpyrazin-2-yl)-N-methylamino]butyloxy}acetic acid tert-butyl ester was hydrolyzed in the same manner as in Example 42, the resulting 2-{4-[N-(5,6-diphenyl-3-methylpyrazin-2-yl)-N-methylamino]butyloxy}acetic acid was treated with the same amount of 1N sodium hydroxide solution to obtain the desired compound as a brownish amorphous.

Sources & evidence

ORD record
ord-c1f360763ad6412988ca59cbf1ed89de
Source dataset
uspto-grants-2007_04
Patent number
US07205302B2

Reaction notes

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