2-Methylbenzenesulfonic acid → 2-Bromomethyl-4,5-dimethyl-1,3-dioxolane

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Reaction Steps

2-Bromo-1,1-dimethoxyethane (188 grams) 2,3-butanediol (100 grams) and toluene sulfonic acid (0.1 grams) were charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, and reflux condenser. The reaction mixture was heated to reflux for a period of about 2 hours. It was then cooled to room temperature, neutralized with potassium carbonate, and filtered. The filtrate was distilled, the desired product 2-bromomethyl-4,5-dimethyl-1,3-dioxolane being obtained as a fraction boiling at 82° C.-85° C. at a pressure of about 12 mm Hg.

Provenance & Evidence