反应详情

2-Bromo-1,1-dimethoxyethane (188 grams) 2,3-butanediol (100 grams) and toluene sulfonic acid (0.1 grams) were charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, and reflux condenser. The reaction mixture was heated to reflux for a period of about 2 hours. It was then cooled to room temperature, neutralized with potassium carbonate, and filtered. The filtrate was distilled, the desired product 2-bromomethyl-4,5-dimethyl-1,3-dioxolane being obtained as a fraction boiling at 82° C.-85° C. at a pressure of about 12 mm Hg.

1. customfitted with a mechanical stirrer
2. temperaturethermometer, and reflux condenser
3. temperatureThe reaction mixture was heated
4. temperatureto reflux for a period of about 2 hours
5. filtrationfiltered
6. distillationThe filtrate was distilled