Methylamine → N-(4-methyl-1,3-dioxan-2-ylmethyl)methylamine
Reaction equation
Br[CH2:2][CH:3]1[O:8][CH:7]([CH3:9])[CH2:6][CH2:5][O:4]1.[OH-].[Na+].[CH3:12][NH2:13]>>[CH3:9][CH:7]1[CH2:6][CH2:5][O:4][CH:3]([CH2:2][NH:13][CH3:12])[O:8]1Participants
4
Conditions
- Temperature
- 50 °C
Procedure
2-bromomethyl-4-methyl-1,3-dioxane (160 grams) and 40% aqueous methylamine (150 ml) were charged into a pressure vessel and agitated for a period of about 6 hours at a temperature of about 50° C. under autogeneous pressure. The reaction mixture was cooled to room temperature and sodium hydroxide (40 grams) was added. The reaction mixture was then extracted with methylene chloride. The extract was dried and the methylene chloride stripped off using a rotary evaporator to yield the desired product N-(4-methyl-1,3-dioxan-2-ylmethyl)methylamine.
Workup
- temperatureThe reaction mixture was cooled to room temperature
- extractionThe reaction mixture was then extracted with methylene chloride
- customThe extract was dried
- customa rotary evaporator
Sources & evidence
- ORD record
- ord-fe87e18df2f843abb07459b083fed972
- Source dataset
- uspto-grants-1981_03
- Patent number
- US04255182
Reaction notes
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