反应详情

2-Acetamido-5-[N-(1-ethylpropyl)aminosulfonyl]-1,3,4-thiadiazole (0.1 mole), and concentrated hydrochloric acid (500 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer and reflux condenser. The mixture is refluxed for a period of about 2 hours, it is then cooled to room temperature, filtered and solvent removed from the filtrate by use of a rotary evaporator. The solid residue is washed with, 10% aqueous sodium carbonate, air dried and then crystallized from isopropanol to yield the desired product 2-amino-5-[N-(1-ethylpropyl)aminosulfonyl]-1,3,4-thiadiazole.

1. customfitted with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. temperatureThe mixture is refluxed for a period of about 2 hours
4. filtrationfiltered
5. customsolvent removed from the filtrate by use of a rotary evaporator
6. washThe solid residue is washed with, 10% aqueous sodium carbonate, air
7. customdried
8. customcrystallized from isopropanol