5-(6-Chloro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine → 5-(6-Chloro-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride

HRID 12715Notes

Reaction equation

HRID 12715 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:4][CH:3]=1>CO>[ClH:1].[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 589942255-(6-Chloro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine

Product 1

HCID 866159485-(6-Chloro-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochlorideYield 193.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(6-Chloro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep90, 4.17 mmol) was dissolved in MeOH (30 ml) and then 2N HClaq (10 ml) was added. After refluxing the reaction mixture for 4 hours, the solvent was removed under vacuum to give 1.05 g of the title compound (quantitative yield).

Workup

  1. addition2N HClaq (10 ml) was added
  2. temperatureAfter refluxing the reaction mixture for 4 hours
  3. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-cc13df9cfbaf42eb8dc5d482c222a399
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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