HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(6-Chloro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine → 5-(6-Chloro-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(6-Chloro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine | HCID 58994225 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(6-Chloro-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride | HCID 86615948 | 193.6% |
Reaction Steps
5-(6-Chloro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep90, 4.17 mmol) was dissolved in MeOH (30 ml) and then 2N HClaq (10 ml) was added. After refluxing the reaction mixture for 4 hours, the solvent was removed under vacuum to give 1.05 g of the title compound (quantitative yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-cc13df9cfbaf42eb8dc5d482c222a399 |
| Source note | uspto-grants-2010_06 |