Hydrochloric Acid → HCID 68586104, compound

HRID 1271515Notes

Reaction equation

HRID 1271515 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[S:13][C@H:14]1[CH2:23][CH2:22][C@@H:21]2[C@@H:16]([CH2:17][C@@H:18]([C:28]([O:30]CC)=[O:29])[N:19](C(OC)=O)[CH2:20]2)[CH2:15]1)=[O:5])C.Cl>>[ClH:12].[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[S:13][C@H:14]1[CH2:23][CH2:22][C@@H:21]2[C@@H:16]([CH2:17][C@@H:18]([C:28]([OH:30])=[O:29])[NH:19][CH2:20]2)[CH2:15]1)([OH:5])=[O:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 91531510HCID 91531510, compound

Product 1

HCID 68586104HCID 68586104, compoundYield 139.5%

Procedure

The intermediate from step B (30 mg, 0.06 mmol) was treated with 6M hydrochloric acid under reflux for 60 h. The solution was cooled down and concentrated in vacuo; followed by washing the resulting solid with acetone (3×5 mL), to give an off-white solid (17 mg, 68%)

Workup

  1. temperatureunder reflux for 60 h
  2. temperatureThe solution was cooled down
  3. concentrationconcentrated in vacuo
  4. washby washing the resulting solid with acetone (3×5 mL)

Sources & evidence

ORD record
ord-f4212c95a36e4db390d063a892696b50
Source dataset
uspto-grants-2007_04
Patent number
US07205313B2

Reaction notes

Loading…