p-Toluenesulfonic acid → HCID 58846560, compound

HRID 1271604Notes

Reaction equation

HRID 1271604 reaction equation
[C:1]([C:4]1[O:8][N:7]=[C:6]([O:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=1)([OH:3])=[O:2].[C:14]1(C)C=CC(S(O)(=O)=O)=C[CH:15]=1>C(O)C>[C:1]([C:4]1[O:8][N:7]=[C:6]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:5]=1)([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 11148145HCID 11148145, compound

Product 1

HCID 58846560HCID 58846560, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(5-Carboxyisoxazol-3-yl)oxyacetic acid (4.0 mmol, Example 74) is dissolved in ethanol (50 mL), to which is added a catalytic amount of p-toluenesulfonic acid (100 mg). After stirring overnight at room temperature, the ethanol was removed and the residue was recrystallized from ethanol/water.

Workup

  1. customthe ethanol was removed
  2. customthe residue was recrystallized from ethanol/water

Sources & evidence

ORD record
ord-86201a8f870742149380140085d3df1a
Source dataset
uspto-grants-2007_04
Patent number
US07205403B2

Reaction notes

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