HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178456517, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 5,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione | HCID 5098605 | — |
| Reactant | 6-hydroxypyridazine-3-carboxylic acid | HCID 178524500 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178456517 | HCID 178456517 | — |
Reaction Steps
To a solution of 1,3-dipropyl-5,6-diaminouracil (2.2 mmol) in methanol was added an equimolar amount of 6-hydroxy-pyridazine-3-carboxylic acid, followed by a slight excess of DCl ((N-(3-(dimethylamino)propyl)-N′ethylcarbodiimide hydrochloride). The mixture was stirred at room temperature for 4–5 hours until complete by TLC. Water was then added and the precipitate removed by filtration. The solid was dissolved in 10% aqueous NaOH (20 mL), then heated at 70° C. for 30 minutes. After cooling to room temperature, the reaction mixture was acidified to pH=5 with 10% hydrochloric acid and the precipitated product collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07205403B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-4cbf557105954faa907b63bdce19f9c5 |
| Source note | uspto-grants-2007_04 |