1-(Methylsulfonyl)spiro[indoline-3,4'-piperidine] hydrochloride → 1-methanesulfonyl-N-(1-phenyl-4-piperidyl)spiro[indoline-3,4'-piperidine]-1'-carboxamide
Reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:14](=[O:22])OC3C=CC=CC=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:24][S:25]([N:28]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:30]2([CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH2:29]1)(=[O:27])=[O:26]>>[CH3:24][S:25]([N:28]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:30]2([CH2:31][CH2:32][N:33]([C:14]([NH:13][CH:10]3[CH2:9][CH2:8][N:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH2:12][CH2:11]3)=[O:22])[CH2:34][CH2:35]2)[CH2:29]1)(=[O:26])=[O:27]Participants
3
Procedure
Compounds of Examples 78 to 83 were obtained by following the same procedure as in Example 77-(2), except that phenyl N-(1-phenyl-4-piperidyl)carbamate and 1-methanesulfonylspiro[indoline-3,4′-piperidine]hydrochloride used in Example 77-(2) were replaced with the corresponding starting material of each desired compound.
Sources & evidence
- ORD record
- ord-1a6c6841850a4a74bdc802a99af05505
- Source dataset
- uspto-grants-2007_04
- Patent number
- US07205417B2
Reaction notes
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