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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1271617Generated: November 2, 2026

1-(Methylsulfonyl)spiro[indoline-3,4'-piperidine] hydrochloride → 1-methanesulfonyl-N-(1-phenyl-4-piperidyl)spiro[indoline-3,4'-piperidine]-1'-carboxamide

https://huagongshe.com/reaction/1271617

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Methylsulfonyl)spiro[indoline-3,4'-piperidine] hydrochlorideHCID 21956084—
ReactantHCID 22936218HCID 22936218—
Product1-methanesulfonyl-N-(1-phenyl-4-piperidyl)spiro[indoline-3,4'-piperidine]-1'-carboxamideHCID 22936223—

Reaction Steps

Compounds of Examples 78 to 83 were obtained by following the same procedure as in Example 77-(2), except that phenyl N-(1-phenyl-4-piperidyl)carbamate and 1-methanesulfonylspiro[indoline-3,4′-piperidine]hydrochloride used in Example 77-(2) were replaced with the corresponding starting material of each desired compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07205417B2
Source datasetuspto-grants-2007_04
ORD IDord-1a6c6841850a4a74bdc802a99af05505
Source noteuspto-grants-2007_04