HCID 69418848, compound → HCID 131726335, compound

HRID 1271634Notes

Reaction equation

HRID 1271634 reaction equation
C(OC([N:8]1[CH:12]([CH:13]=[CH:14][C:15]2[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=2)[CH2:11][CH2:10][CH:9]1[C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@H:25]1[C:29]#[N:30])=[O:23])=O)(C)(C)C>C(O)C.[Pd]>[CH3:21][C:17]1[CH:16]=[C:15]([CH2:14][CH2:13][CH:12]2[NH:8][C@H:9]([C:22]([N:24]3[CH2:28][CH2:27][CH2:26][C@H:25]3[C:29]#[N:30])=[O:23])[CH2:10][CH2:11]2)[CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 1

HCID 69418848HCID 69418848, compound

Product 1

HCID 131726335HCID 131726335, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2-(2-(S)-cyano-pyrrolidine-1-carbonyl)-5-(R/S)-(2-m-tolyl-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (Example 23) (50 mg) and 10% Pd/C(10 mg) in ethanol (5mL) was stirred under H2 balloon overnight. The catalyst was removed by filtration, and the filtrate was concentrated to provide the desired product.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-4e7b1cfa34df45968690a55102097343
Source dataset
uspto-grants-2007_04
Patent number
US07205409B2

Reaction notes

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