HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1271648Generated: October 25, 2026
Isopropanol → 4-Chloro-3-hydroxy-benzoic acid isopropyl ester
https://huagongshe.com/reaction/1271648
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 4-Chloro-3-hydroxybenzoic acid | HCID 141872 | — |
| Product | 4-Chloro-3-hydroxy-benzoic acid isopropyl ester | HCID 69418989 | 75% |
Reaction Steps
4-Chloro-3-hydroxy-benzoic acid (100 mg, 0.58 mmol) and 1 mL of isopropanol were mixed and then heated to 85° C. for overnight. The mixture was then concentrated in vacuum and the resulting residue was purified by flash chromatography (8–20% EtOAc/Hex) to give the desired ester (94 mg, 75%). MS (DCI) m/z 215 (M+H)+, 232 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07205409B2 |
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| Source dataset | uspto-grants-2007_04 |
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| ORD ID | ord-d160994da4dc4be5bb9d588354b12d3d |
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| Source note | uspto-grants-2007_04 |
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