反应详情

温度

85 °C

4-Chloro-3-hydroxy-benzoic acid (100 mg, 0.58 mmol) and 1 mL of isopropanol were mixed and then heated to 85° C. for overnight. The mixture was then concentrated in vacuum and the resulting residue was purified by flash chromatography (8–20% EtOAc/Hex) to give the desired ester (94 mg, 75%). MS (DCI) m/z 215 (M+H)+, 232 (M+NH4)+.

1. concentrationThe mixture was then concentrated in vacuum
2. customthe resulting residue was purified by flash chromatography (8–20% EtOAc/Hex)