HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-fluorophenol → 5-Fluoro-2(3H)-benzoxazolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-fluorophenol | HCID 2735917 | — |
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Fluoro-2(3H)-benzoxazolone | HCID 287208 | 67% |
Reaction Steps
Carbonyl diimidazole (7.6 g) was added to a solution of 2-amino-4-fluorophenol (5 g, 39 mmol) in dichloromethane (0.100 ml). After 14 hours the solution was washed with 5M aqueous HCl, water, and dried over magnesium sulfate. The solution was filtered through a plug of silica and evaporated affording a white solid (4.0 g, 66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07205408B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-4546198c3ac949d9ac091528485bf21a |
| Source note | uspto-grants-2007_04 |