Hydrochloric Acid → Benzoic acid, 2,4-difluoro-, ethyl ester

HRID 1271689Notes

Reaction equation

HRID 1271689 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl.[CH2:13](O)[CH3:14]>>[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:13][CH3:14])=[O:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 741022,4-Difluorobenzoic acid

Product 1

HCID 2737170Benzoic acid, 2,4-difluoro-, ethyl esterYield 100%

Procedure

A solution of 2,4-difluoro-benzoic acid (19.3 g) in dry ethanol (200 ml) was treated with gaseous hydrochloric acid for 0.25 hours, then heated to reflux for 4 hours. Evaporation gave a white solid (22.7 g, 100%).

Workup

  1. temperatureheated
  2. temperatureto reflux for 4 hours
  3. customEvaporation

Sources & evidence

ORD record
ord-6eb1b16cd8bd42268195e85d50f18ed6
Source dataset
uspto-grants-2007_04
Patent number
US07205408B2

Reaction notes

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