反应详情

温度

40 °C

5-(6-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione (Prep92, 267 mg, 0.82 mmol) was dissolved in THF (10 ml) and then 1N HClaq (0.82 ml) was added. The solution was stirred at 40° C. for 1.5 hours. TEA (116 μl, 0.83 mmol) was added and the solvent was removed in vacuum at room temperature. Residue was freeze dried to give a white powder that was used in the next step without further purification (quantitative yield).

1. addition1N HClaq (0.82 ml) was added
2. customthe solvent was removed in vacuum at room temperature
3. customdried
4. customto give a white powder that
5. customwas used in the next step without further purification (quantitative yield)