反应详情

4-(2-oxopyridin-1(2H)-yl)benzoic acid (1 g, 4.6 mmol) was ]mixed with 10 mL of 1,2-dichloroethane. To this suspension was added SOCl2 (6 mL), and the mixture was refluxed for 1.5 h. The mixture was reduced in vacuo. The remaining traces of SOCl2 were removed by adding 1,2-dichloroethane (2×5 mL) and evaporating to dryness to yield 4-(2-oxopyridin-1(2H)-yl)benzoyl chloride as a white solid.

1. temperaturethe mixture was refluxed for 1.5 h
2. customThe remaining traces of SOCl2 were removed
3. additionby adding 1,2-dichloroethane (2×5 mL)
4. customevaporating to dryness