反应详情

A mixture of 3-(2-amino-4-chloro-6-fluoro-3-methoxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione (0.5 g, 1.4 mmol) and dimethylformamide dimethylacetal (0.8 g, 7 mmol) was refluxed for 4 hr under a blanket of nitrogen. Excess reagent was removed in vacuo and product extracted with ether. Solvent was removed to afford a residue which was chromatographed on silica gel. Elution of the column with hexane-ethyl acetate (6:4) afforded the title compound (0.22 g).

1. temperaturewas refluxed for 4 hr under a blanket of nitrogen
2. customExcess reagent was removed in vacuo and product
3. extractionextracted with ether
4. customSolvent was removed
5. customto afford a residue which
6. customwas chromatographed on silica gel
7. washElution of the column with hexane-ethyl acetate (6:4)