Propargyl bromide → HCID 87836339, compound

Participants

Reaction Steps

The mixture of 1-(2-amino-4-chloro-6-fluoro-3-hyroxyphenyl)(3-fluoropropyl)-tetrazolinone (0.28 g), propargyl bromide (0.13 g), and potassium carbonate (0.14 g) in acetonitrile (5 ml) was heated under reflux for 0.5 hour. The solvent and excess reagent were removed under reduced pressure. The residue was purified by a silica gel column, eluted with ethyl acetate to give the desired product (0.33 g).

Provenance & Evidence