Hydrazine → HCID 22131447, compound

HRID 1271785Notes

Reaction equation

HRID 1271785 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][N:13]1C(=O)C2=CC=CC=C2C1=O.NN>CCO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][NH2:13]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 22131444HCID 22131444, compound

Product 1

HCID 22131447HCID 22131447, compoundYield 107.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-(2-quinolyl)methoxy phthalimide (782 mg) was suspended in 95% EtOH and hydrazine (0.15 mL) was added. The reaction mixture was stirred overnight and then filtered. The filtrate was concentrated under reduced pressure and then taken up in a small amount of dichloromethane. The small amount of remaining phthalhydrazide was then removed by filtration. The filtrate was concentrated under reduced pressure to give the title compound (480 mg) as a yellow oil. MS(CI) m/e 175 (M+H)+.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customThe small amount of remaining phthalhydrazide was then removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-164d1679b693489594483b88ee377c1e
Source dataset
uspto-grants-2007_04
Patent number
USRE039591E1

Reaction notes

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