HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1271791Generated: November 2, 2026
Propionic Acid → 2-(5,6-Dimethoxy-3,3-dimethyl-1-indanylidene)-4,4-dimethyl-3-oxo-pentanonitrile
https://huagongshe.com/reaction/1271791
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| Reactant | z1-Indanone, 5,6-dimethoxy-3,3-dimethyl- | HCID 138129 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 2-(5,6-Dimethoxy-3,3-dimethyl-1-indanylidene)-4,4-dimethyl-3-oxo-pentanonitrile | HCID 69427051 | 50% |
Reaction Steps
44 g (0.2 mol) of 5,6-dimethoxy-3,3-dimethyl-1-indanone, 25 g (0.2 mol) of pivaloylacetonitrile, 32 g of propionic acid and 17 g of ammonium acetate are mixed in 80 g of xylene and heated at 120° C. for 7 hours. After the system has been cooled to room temperature and the organic phase has been washed, the xylene is distilled off, and the crude product which remains is recrystallized in methanol. Yield: 50% theory; E1/1730 (λmax 373 nm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07208142B2 |
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| Source dataset | uspto-grants-2007_04 |
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| ORD ID | ord-eb3f1430fc584b66bb8f417be2d4e2de |
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| Source note | uspto-grants-2007_04 |
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