反应详情

温度

120 °C

44 g (0.2 mol) of 5,6-dimethoxy-3,3-dimethyl-1-indanone, 25 g (0.2 mol) of pivaloylacetonitrile, 32 g of propionic acid and 17 g of ammonium acetate are mixed in 80 g of xylene and heated at 120° C. for 7 hours. After the system has been cooled to room temperature and the organic phase has been washed, the xylene is distilled off, and the crude product which remains is recrystallized in methanol. Yield: 50% theory; E1/1730 (λmax 373 nm).

1. temperatureAfter the system has been cooled to room temperature
2. washthe organic phase has been washed
3. distillationthe xylene is distilled off
4. customthe crude product which remains is recrystallized in methanol