Water → HCID 18454874, compound

HRID 1271808Notes

Reaction equation

HRID 1271808 reaction equation
C([CH2:8][NH:9][CH2:10][CH:11]([OH:49])[CH2:12][N:13]1[CH2:24][CH2:23][N:22]([CH2:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:21][CH2:20][N:19]([CH2:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:18][CH2:17][N:16]([CH2:41][C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:15][CH2:14]1)C1C=CC=CC=1.O>CO.[Pd]>[CH3:8][NH:9][CH2:10][CH:11]([OH:49])[CH2:12][N:13]1[CH2:14][CH2:15][N:16]([CH2:41][C:42]([O:44][C:45]([CH3:46])([CH3:47])[CH3:48])=[O:43])[CH2:17][CH2:18][N:19]([CH2:33][C:34]([O:36][C:37]([CH3:40])([CH3:38])[CH3:39])=[O:35])[CH2:20][CH2:21][N:22]([CH2:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23][CH2:24]1

Participants

5

Reactant 2

HCID 962WaterHCID 69486256HCID 69486256, compound

Product 1

HCID 18454874HCID 18454874, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

69.2 g (100 mmol) of 10-(3-benzylmethylamino-2-hydroxypropyl)-1,4,7-tris-(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane is dissolved in 500 ml of methanol, mixed with 40 ml of water, and 10 g of palladium catalyst (20% Pd/C) is added. It is hydrogenated for 8 hours at 50° C. under normal pressure. Catalyst is filtered out, and the filtrate is evaporated to the dry state in a vacuum.

Workup

  1. additionis added
  2. filtrationCatalyst is filtered out
  3. customthe filtrate is evaporated to the dry state in a vacuum

Sources & evidence

ORD record
ord-a0c24055890142d990123f50a4632de1
Source dataset
uspto-grants-2007_04
Patent number
US07208140B2

Reaction notes

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