3-(2,6dichloro-4-(benzyloxy)phenoxy)-1-propyl alcohol → HCID 18454988, compound

HRID 1271829Notes

Reaction equation

HRID 1271829 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([O:13]CC2C=CC=CC=2)[CH:10]=[C:9]([Cl:21])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][OH:8].[H][H]>[Pd].C(O)C>[Cl:1][C:2]1[CH:12]=[C:11]([OH:13])[CH:10]=[C:9]([Cl:21])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][OH:8]

Participants

5

Reactant 2

HCID 120568873-(2,6dichloro-4-(benzyloxy)phenoxy)-1-propyl alcoholHCID 178418361HCID 178418361, compound2×

Product 1

HCID 18454988HCID 18454988, compoundYield 93.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

This compound was prepared in a manner analogous to that of Step B of Example 1, by the treatment of 11.8 grams (0.036 mole) of 3-[2,6-dichloro-4-(phenylmethoxy)phenoxy]propan-1-ol with hydrogen gas in the presence of a catalytic amount of 10% palladium on carbon in ethanol using a Parr hydrogenation apparatus. Following the theoretical uptake of hydrogen, the reaction mixture was and filtered and concentrated under reduced pressure to a residue, yielding 8.0 grams of the subject compound.

Workup

  1. customThis compound was prepared in a manner analogous to that of Step B of Example 1
  2. filtrationfiltered
  3. concentrationconcentrated under reduced pressure to a residue

Sources & evidence

ORD record
ord-3657d23dd5754bba8161abf3a73df7d6
Source dataset
uspto-grants-2007_04
Patent number
US07208450B2

Reaction notes

Loading…